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Barreiro, Luis
One or more keywords matched the following properties of Barreiro, Luis
PropertyValue
keywords Functional Genomics, Population Genetics, Natural Selection, Innate Immunity, Population Variation
overview Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.
One or more keywords matched the following items that are connected to Barreiro, Luis
Item TypeName
Concept Genetics, Population
Concept Selection, Genetic
Concept Genetic Variation
Concept Population Groups
Concept Population Dynamics
Concept DNA Copy Number Variations
Concept Metagenomics
Concept Immunity, Innate
Concept Population
Academic Article Functional comparison of innate immune signaling pathways in primates.
Academic Article Social environment is associated with gene regulatory variation in the rhesus macaque immune system.
Academic Article Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.
Academic Article Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations.
Academic Article Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.
Academic Article Seasonal variation in human gut microbiome composition.
Academic Article Mycobacterial infection induces a specific human innate immune response.
Academic Article The epigenomic landscape of African rainforest hunter-gatherers and farmers.
Academic Article Evolutionary genetics evidence of an essential, nonredundant role of the IFN-? pathway in protective immunity.
Academic Article Evolutionary genetic dissection of human interferons.
Academic Article Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients.
Academic Article Inferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data set.
Academic Article BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis.
Academic Article The contribution of admixture to primate evolution.
Academic Article The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region.
Academic Article DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: From population stratification to a possible advantage of the 7/5 heterozygous genotype.
Academic Article Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection.
Academic Article Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America.
Academic Article Natural selection has driven population differentiation in modern humans.
Academic Article From evolutionary genetics to human immunology: how selection shapes host defence genes.
Academic Article The demographic history and mutational load of African hunter-gatherers and farmers.
Academic Article Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.
Academic Article DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population.
Academic Article The role played by natural selection on Mendelian traits in humans.
Academic Article Formulating a historical and demographic model of recent human evolution based on resequencing data from noncoding regions.
Academic Article The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease.
Academic Article Social networks predict gut microbiome composition in wild baboons.
Academic Article TLR3 deficiency in patients with herpes simplex encephalitis.
Academic Article Gene set signature of reversal reaction type I in leprosy patients.
Academic Article Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets.
Academic Article Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense.
Academic Article Genetic and evolutionary determinants of human population variation in immune responses.
Academic Article When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection.
Academic Article Widespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection.
Academic Article Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission.
Academic Article Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility.
Academic Article Social status alters immune regulation and response to infection in macaques.
Academic Article Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens.
Academic Article Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.
Academic Article Signatures of purifying and local positive selection in human miRNAs.
Academic Article Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles.
Academic Article Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers.
Academic Article Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.
Academic Article Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.
Academic Article Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.
Academic Article Social affiliation predicts mitochondrial DNA copy number in female rhesus macaques.
Academic Article Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists.
Academic Article Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques.
Academic Article Defining trained immunity and its role in health and disease.
Academic Article Evolutionary and population (epi)genetics of immunity to infection.
Academic Article Trained immunity, tolerance, priming and differentiation: distinct immunological processes.
Academic Article Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity.
Academic Article Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4+ T Cell Activation and Mycobacterium tuberculosis Control.
Academic Article A multilayered immune system through the lens of unconventional T cells.
Academic Article Genetic ancestry effects on the response to viral infection are pervasive but cell type specific.
Academic Article Evolution of immune genes is associated with the Black Death.
Grant Stress and the Genome: Testing the Impact of Social Effects on Gene Regulation
Grant Stress and the Genome: Testing the Impact of Social Effects on Gene Regulation
Academic Article [The Black Death, natural selection and susceptibility to auto-immune disorders].
Academic Article Reply to Barton et al: signatures of natural selection during the Black Death.
Academic Article The evolutionary tale of lactase persistence in humans.
Academic Article Epigenetic variation impacts individual differences in the transcriptional response to influenza infection.
Academic Article Shaping immunity: The influence of natural selection on population immune diversity.
Search Criteria
  • Functional
  • Genomics Population
  • Genetics
  • Natural Selection
  • Innate Immunity
  • Population
  • Variation